No products in the cart.
A 2014 study has investigated the safety and efficacy of novel light sources for skin rejuvenation and the stimulation of dermal collagen synthesis based on low-pressure and mid-pressure gas discharge lamps. These light sources, in contrast to lasers and LEDs, allow simultaneous treatment with a tailored spectrum composed of several spectral bands that are effective in PBM.
The study, which is the first prospective clinical trial investigating the safety and efficacy of these light sources, included 77 volunteers who received 30 treatments of either red light therapy (RLT), intense red light therapy (ELT), or no treatment (control). The volunteers were evaluated at the beginning of the study (t0), after 30 treatments (t30), and at long-term follow-up periods.
The results of the study showed that the volunteers experienced significant improvements in their personal assessments of skin feeling and complexion, in clinical outcomes as assessed by collagen density and skin roughness measurements, and in the reduction of fine lines and wrinkles as assessed by three blinded evaluators comparing t0 and t30 photographs. The long-term follow-up also showed that the volunteers who continued the therapy had significantly better results.
The study also found that there was no significant difference between the RLT and ELT groups in terms of skin complexion and skin feeling. However, there was a difference in collagen density, roughness, and wrinkle status between both treatment groups and the control group. The subgroup analyses found no differences between the two RLT treatment groups and the two ELT treatment groups.
The proposed underlying mechanisms for the efficacy of PBM in skin rejuvenation include the photostimulation of terminal molecules in the electron transport chain and the subsequent adenosine triphosphate (ATP) concentration increase, along with the selective light-driven activation of water molecules, thereby enhancing metabolic exchange and influencing the ion transporter systems found in cellular membranes. The study also found that the increase in collagen density could be a surrogate marker for fibroblast activity.
One limitation of the study was the lack of histologic examinations following skin biopsies, which could have provided more invasive monitoring methods. However, the study used ultrasonographic collagen assessment as a feasible noninvasive methodology for monitoring dermal density during the senescence process.
Overall, the study provides evidence for the safety and efficacy of RLT and ELT as large-area and full-body treatment modalities for skin rejuvenation and improvements in skin feeling and skin complexion. The application of RLT and ELT provides a safe, non-ablative, non-thermal, atraumatic photobiomodulation treatment of skin tissue with high patient satisfaction rates. These light therapies can extend the spectrum of anti-aging treatment options available to patients looking for mild and pleasant light-only skin rejuvenation.
Future studies could investigate the optimal treatment parameters for these light therapies and evaluate gender-specific differences in treatment outcomes. Additionally, the influence of PBM on scar tissue should be subject to further investigation. Nevertheless, this study provides promising results for the use of PBM in skin rejuvenation and warrants further investigation in clinical practice.